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JAIN LAB

OXYGEN | VITAMINS | AGING

PUBLICATIONS

IN VIVO PROTEIN TURNOVER NOMINATES MYBBP1A AS A MEDIATOR OF THE HYPEROXIA RESPONSE

X. Chen, A. G. Haribowo, A. H. Baik, A Fossati, E. Stevenson, Y. R. Chen, N. S. Reyes, T. Peng, M. A. Matthay, M. Traglia, A. R. Pico, D. F. Jarosz, A. Buchwalter, S. Ghaemmaghami, D. L. Swaney, I. H. Jain. In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Science Advances. 9. (2023)

News: https://gladstone.org/news/dynamic-picture-how-we-respond-high-or-low-oxygen-levels

MECHANISMS OF OXYGEN TOXICITY

A. H. Baik*, A. G. Haribowo*, X. Chen*, B. B. Queliconi, A. M. Barrios, A. Garg, M. Maishan, A. R. Campos, M. A. Matthay, I. H. Jain. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Molecular Cell. 83, 1-19. [*equal contribution] (2023)

News: https://gladstone.org/news/researchers-discover-how-too-much-oxygen-damages-cells-and-tissues

2023

FUEL REWIRING IN HYPOXIA

A. M. Midha*, Y. Zhou*, B. B. Queliconi, A. M. Barrios, C. O. Y. Fong, J. E. Blecha, H. VanBrocklin, Y. Seo, I. H. Jain. Organ-Specific Fuel Rewiring in Acute and Chronic Hypoxia Redistributes Glucose and Fatty Acid Metabolism. Cell Metabolism. 35, 504-516. [*equal contribution] (2023)

Preview: https://www.cell.com/cell-metabolism/pdf/S1550-4131(23)00047-5.pdf

News: https://gladstone.org/news/how-high-altitude-changes-your-bodys-metabolism

2023

GOLDILOCKS' OXYGEN PRINCIPLE

W. R. Flanigan, I. H. Jain. The Goldilocks Oxygen Principle: not too little and not too much. Nature Cardiovascular Research. 1, 1101–1103 (2022)

2022

FERROPTOSIS AND PDAC THERAPY RESISTANCE

M. Ravichandran, J. Hu…B. R. Desousa…I. H. Jain…R. M. Perera. Coordinated transcriptional and catabolic programs support iron-dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer. Cancer Discovery. OF1–OF22 (2022)

2022

HYPOXIA SENSING IN AIRWAY STEM CELLS

M. Shivaraju, U. K. Chitta, R. M. H. Grange, I. H. Jain…J. Rajagopal. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 371, 52-57 (2021).

2021

TURNING THE OXYGEN DIAL: BALANCING THE HIGHS & LOWS

A. H. Baik, I. H. Jain. Turning the oxygen dial: balancing the highs and lows. Trends in Cell Biology. (2020)

2020

PEROXISOMAL LIPID METABOLISM AS A HYPOXIA ADAPTATION

I. H. Jain*, S. E. Calvo*, A. L. Markhard…V. K. Mootha. Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism. Cell, 181, 1-12 (2020). [*, **equal contribution]

2020

HYPOXIA THERAPY NORMALIZES BRAIN HYPEROXIA IN

MITOCHONDRIAL DISEASE

I. H. Jain*, L. Zazzeron*, Goldberger, O…W.M. Zapol**, V. K. Mootha**. Leigh syndrome mouse model can be rescued by interventions that normalize brain hyperoxia, but not HIF activation. Cell Metabolism, 30, 1-9 (2019)

Preview: https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30507-8.pdf

2019

HYPOXIA REVERSES NEUROLOGICAL LESIONS IN MITOCHONDRIAL DISEASE

M. Ferrari*, I. H. Jain*, Goldberger, O…V. K. Mootha**, W.M. Zapol**. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. PNAS, 114 (21), E4241-E4250 (2017). * equal contribution

News: https://www.hhmi.org/news/low-oxygen-reverses-mitochondrial-disease-mice

2017

HYPOXIA AS A THERAPY FOR MITOCHONDRIAL DISEASE

I. H. Jain, L. Zazzeron, R. Goli…F. Zhang, W. Goessling, W. M. Zapol, V. K. Mootha. Hypoxia as a therapy for mitochondrial disease. Science, 352 (6281), 54-61 (2016).

News: https://www.science.org/content/article/oxygen-deprivation-counters-deadly-mitochondrial-disease-animals

Perspective: https://www.science.org/doi/pdf/10.1126/science.aaf5248

2016

CHROMOSOME ORDERING & SEGREGATION IN CYANOBACTERIA

I. H. Jain*, V. Vijayan*, E.K. O’Shea. Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria. PNAS, 109 (34), 13638-13643 (2012). [*equal contribution]

2012

CIRCADIAN GENE EXPRESSION IN CYANOBACTERIA

V. Vijayan, I. H. Jain, E.K. O’Shea. A high resolution map of a cyanobacterial transcriptome. Genome Biology, 12:R47 (2011). Highly accessed article.

2011

CONNEXIN43 AND BONE REGENERATION

A. D. Hoptak-Solga, S. Nielsen, I. H. Jain, R. Thummel, D. Hyde, and M. K. Iovine. Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Developmental Biology, (2008).

2008

PULSATILE BONE GROWTH

I. H. Jain, C. Stroka, J. Yan, W. Huang, M. K. Iovine. Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation. Developmental Dynamics, 236, 2668-2674 (2007)

2007

EFFECTS OF RAPID EXPANSION ON GLASS SURFACES

A. Sharma, H. Jain, J. O. Carnali, I. H. Jain. Inhomogeneous evolution of a glass surface via free, rapid expansion. Applied Physics Letters, 83, 2802-2804 (2003).

2003

2023

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